| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372880 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives exhibited potent cytoprotective effect from rotenone toxicity. Lead optimization focused on the CC50/EC50 ratio and DMPK properties led to the overall improvement of the compound profile of this series with high CC50/EC50 ratio (92 for 1f), good metabolic stability in rat microsomes and medium to high aqueous solubility.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives: Their cytoprotection effect from rotenone toxicity and preliminary DMPK properties](/preview/png/1372880.png "First Page Preview: Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives: Their cytoprotection effect from rotenone toxicity and preliminary DMPK properties")
Authors
Yuefen Zhou, Gang Liu, Jinhua Chen, P.S. Murali Mohan Reddy, Il Sang Yoon, Menghua Zhang, Bin Zhang, Jack R. Barber, Shi Chung Ng,