Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372883 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Knowledge of the biotransformation and pharmacokinetics of the antiretroviral agent nevirapine is still insufficient. In order to trace rash inducing metabolites of nevirapine, we devised a short and efficient multi-gram synthesis of a nevirapine analog that can be coupled to azide containing compounds by click chemistry.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sylvain Bernard, Daniel Defoy, Yves L. Dory, Klaus Klarskov,