| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372891 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
A series of pyrimidine analogues derived from ATC0175 were potent antagonists of human MCH-R1 in vitro with improved receptor selectivity. One example was shown to inhibit food intake and decrease body weight in a chronic study. However observed effect was most likely not due to interaction with the MCH-R1.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Graeme Semple, Thuy-Anh Tran, Bryan Kramer, Debbie Hsu, Sangdon Han, Juyi Choi, Pureza Vallar, Martin D. Casper, Ning Zou, Erin K. Hauser, William Thomsen, Kevin Whelan, Dipanjan Sengupta, Michael Morgan, Yoshinori Sekiguchi, Kosuke Kanuma,