Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372894 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Peptide nucleic acid (PNA) is a successful DNA/RNA mimic. A major challenge for research is to invent chemically modified PNAs that retain the favorable properties of the parent compound while improving biological recognition. Here, we test modified PNAs containing [bis-o-(aminoethoxy)phenyl]pyrrolocytosine bases designed to engage guanine with an additional hydrogen bond. We observe elevated melting temperatures, localization to cellular compartments, and allele-selective inhibition of mutant huntingtin protein expression.
Graphical abstractModified PNAs enter cells and inhibit expression of huntingtin.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jiaxin Hu, David W. Dodd, Robert H.E. Hudson, David R. Corey,