| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372895 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
The special ergoline 1 is a highly potent, selective antagonist of the chemokine receptor CXCR3. The surprising selectivity of this LSD-related compound can be explained by different electronic and steric properties of the ergoline core structure caused by the urea portion of the molecule. Discovery, biopharmaceutical properties and first derivatives of this promising lead compound are discussed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gebhard Thoma, Rolf Baenteli, Ian Lewis, Trixie Wagner, Lukas Oberer, Wolfgang Blum, Fraser Glickman, Markus B. Streiff, Hans-Guenter Zerwes,