2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2

Analogues of the 2-oxoglutarate cosubstrate of the human oxygen sensing enzyme prolyl hydroxylase domain 2 (PHD2) with variations in the potential iron-chelating group were screened as inhibitors and for binding (using non-denaturing electrospray ionization mass spectrometry) to PHD2.

Graphical abstract2-Oxoglutarate analogues were evaluated as inhibitors of the human oxygen sensing enzyme prolyl hydroxylase domain 2 and screened for binding by non-denaturing electrospray ionization mass spectrometry.Figure optionsDownload full-size imageDownload as PowerPoint slide