| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372899 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Halogenated furanones, a group of natural products initially isolated from marine red algae, are known to inhibit bacterial biofilm formation, swarming, and quorum sensing. However, their molecular targets and the precise mode of action remain elusive. Herein, we show that a naturally occurring brominated furanone covalently modifies and inactivates LuxS (S-ribosylhomocysteine lyase, EC 4.4.1.21), the enzyme which produces autoinducer-2 (AI-2).
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tianzhu Zang, Bobby W.K. Lee, Lisa M. Cannon, Kathryn A. Ritter, Shujia Dai, Dacheng Ren, Thomas K. Wood, Zhaohui Sunny Zhou,