| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372921 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Structure–activity relationship of sphingosine-1-phosphate receptor agonists was examined. Cinnamyl derivative 1 was modified to improve S1P1 agonistic activity as well as selectivity over S1P3 agonistic activity. Dihydronaphthalene derivative 10d was identified as a potent S1P1 receptor agonist with high selectivity against S1P3 and enhanced efficacy in lowering peripheral lymphocyte counts in mice.
Graphical abstractStructure–activity relationship of sphingosine-1-phosphate receptor agonists was examined. Novel S1P agonists with a dihydronaphthalene scaffold were identified.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Haruto Kurata, Kensuke Kusumi, Kazuhiro Otsuki, Ryo Suzuki, Masakuni Kurono, Yuka Takada, Hiroki Shioya, Takaki Komiya, Hirotaka Mizuno, Takeji Ono, Hiroshi Hagiya, Masashi Minami, Shinji Nakade, Hiromu Habashita,