Efficient synthesis, structural characterization and anti-microbial activity of chiral aryl boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose

A simple and efficient synthetic approach toward a series of chiral aryl boronate esters, starting from d-xylose, as anti-microbial agents, is described herein. Minimum inhibitory concentration and zone of inhibition revealed that these derivatives exhibit potent anti-bacterial and anti-fungal properties. Herein, we report the first anti-microbial activity of this class of compounds. All products have been characterized by NMR (1H, 13C and 11B), IR, elemental and mass spectral study.

Graphical abstractA simple and efficient synthetic approach toward a series of chiral aryl boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose, as anti-microbial agents, is described herein. Minimum inhibitory concentration and zone of inhibition revealed that these derivatives exhibit potent anti-bacterial and anti-fungal properties. Herein, we report the first anti-microbial activity of this class of compounds.Figure optionsDownload full-size imageDownload as PowerPoint slide