| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372923 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A series of novel 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl butyric acid derivatives were synthesized and evaluated for their antagonistic activity for endothelin-1-induced contraction in rabbit aorta. Within this series of compounds, 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-cyano-3,3-diphenylpropionic acid (4) displays comparable potency with ambrisentan (1), and warrants further investigation.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Jun Xia, Jianfei Song, Le Zhen, Xiuling Zhang, Xiantao Lei, Lina Zheng, Qiujuan Wang, Hongbin Sun,