Sannastatin, a novel toxic macrolactam polyketide glycoside produced by actinomycete Streptomyces sannanensis

A new rare 20-membered macrocyclic lactam incorporating a diene conjugated olefin, designated sannastatin (1), together with the known structurally related vicenistatin (2), has been isolated from the cultures of Streptomyces sannanensis, a bacteria found in the feces of Ailuropoda melanoleuca. The structure of the new compound was established on the basis of extensive spectroscopic analyses including 1D- and 2D-NMR (1H–1H COSY, TOCSY, HSQC, HMBC, and NOESY) experiments. Compounds 1 and 2 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina) larvae.

Graphical abstractA new rare 20-membered macrocyclic lactam sannastatin (1), together with the known analogue vicenistatin (2), was isolated from the cultures of Streptomyces sannanensis found in the feces of Ailuropoda melanoleuca. Compounds 1 and 2 exhibited significant growth inhibitory activity against Artemia salina.Figure optionsDownload full-size imageDownload as PowerPoint slide