| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372930 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
AMPA receptors (AMPARs) are an important therapeutic target in the CNS. A series of substituted benzoxazinone derivatives with good to very good in vitro activity as positive allosteric AMPAR modulators was synthesized and evaluated. The appropriate substituent choice on the benzoxazinone fragment improved the affinity towards the AMPA receptor significantly in comparison to our lead molecule CX614.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rudolf Mueller, Stanislaw Rachwal, Martina E. Tedder, Yong-Xin Li, Sheng Zhong, Aidan Hampson, Jolanta Ulas, Mark Varney, Lena Nielsson, Gary Rogers,