| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372938 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Markedly inhibitory effects of hybrid liposomes (HL-n) composed of 90 mol % l-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol % polyoxyethylene(n) dodecyl ethers on the growth of adult T-cell leukemia cells were obtained for the first time. It is noteworthy that HL-n could selectively accumulate into the adult T-cell leukemia cells and induce apoptosis via caspase-3 activation.
Graphical abstractHybrid liposomes composed of 90 mol % l-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol % polyoxyethylene(n) dodecyl ethers (C12(EO)n) could selectively accumulate into adult T-cell leukemia (ATL) cells and induce apoptosis via caspase-3 activation.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Authors
Yuji Komizu, Mamiko Yukihara, Ryusho Kariya, Koichi Goto, Seiji Okada, Ryuichi Ueoka,