Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase

Hexacyclic derivatives share vital pharmacological properties, considered useful in Alzheimer’s disease. The aim of this study was synthesis and its evaluation for acetyl cholinesterase inhibitory activity of novel hexacyclic analogues. Compound 4f, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC50 0.72 μmol/L.

Graphical abstractCompound 4f, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC50 0.72 μmol/L.Figure optionsDownload full-size imageDownload as PowerPoint slide