| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372950 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
SAR of a novel series of pyridazine-derived γ-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42 and Aβ40, and maintain the levels of total Aβ. Furthermore, 25 demonstrated excellent pharmacokinetic parameters as well as good CNS penetration in the rat.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Zehong Wan, Adrian Hall, Yun Jin, Jia-Ning Xiang, Eric Yang, Andrew Eatherton, Beverley Smith, Guang Yang, Haihua Yu, Ju Wang, Liang Ye, Lit-Fui Lau, Ting Yang, William Mitchell, Wei Cai, Xiaomin Zhang, Yingxia Sang, Yonghui Wang, Zhaolong Tong,