Article ID Journal Published Year Pages File Type
1372955 Bioorganic & Medicinal Chemistry Letters 2011 5 Pages PDF
Abstract

Starting from small molecule mTOR inhibitor Torin1, replacement of the piperazine ring with a phenyl ring resulted in a new series of mTOR inhibitors (as exemplified by 10) that showed superior potency and selectivity for mTOR, along with significantly improved mouse liver microsome stability and a longer in vivo half-life.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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