Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1372955 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Starting from small molecule mTOR inhibitor Torin1, replacement of the piperazine ring with a phenyl ring resulted in a new series of mTOR inhibitors (as exemplified by 10) that showed superior potency and selectivity for mTOR, along with significantly improved mouse liver microsome stability and a longer in vivo half-life.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Qingsong Liu, Jinhua Wang, Seong A. Kang, Carson C. Thoreen, Wooyoung Hur, Hwan Geun Choi, David L. Waller, Taebo Sim, David M. Sabatini, Nathanael S. Gray,