| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372959 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Starting from thienobenzopyran HTS hit 1, co-crystallization, molecular modeling and metabolic analysis were used to design potent and metabolically stable inhibitors of PI3-kinase. Compound 15 demonstrated PI3K pathway suppression in a mouse MCF7 xenograft model.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Steven T. Staben, Michael Siu, Richard Goldsmith, Alan G. Olivero, Steven Do, Daniel J. Burdick, Timothy P. Heffron, Jenna Dotson, Daniel P. Sutherlin, Bing-Yan Zhu, Vickie Tsui, Hoa Le, Leslie Lee, John Lesnick, Cristina Lewis, Jeremy M. Murray,