| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372961 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
The synthesis and SAR studies of a novel N-aryl pyridinone class of p38 kinase inhibitors are described. Systematic structural modifications to the HTS lead, 5, led to the identification of (−)-4a as a clinical candidate for the treatment of inflammatory diseases. Additionally, the chiral synthesis and properties of (−)-4a are described.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shaun R. Selness, Rajesh V. Devraj, Balekudru Devadas, John K. Walker, Terri L. Boehm, Richard C. Durley, Huey Shieh, Li Xing, Paul V. Rucker, Kevin D. Jerome, Alan G. Benson, Laura D. Marrufo, Heather M. Madsen, Jeff Hitchcock, Tom J. Owen,