| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372978 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
Novel fluorescently-labeled conjugates of risedronate were synthesized using an epoxide linker, enabling conjugation of risedronate via its pyridyl nitrogen with the aromatic succinimidyl esters. The compounds were characterized by using 1H NMR, 13C NMR, 31P NMR, UV–vis and fluorescence emission spectroscopies. Biological activity assays showed that the conjugates 14 and 15 exhibited photodynamic inactivation of Bacillus subtilis (ATCC 6633) with 91% and 47% bacterial lethality at 10 μM upon visible light irradiation, respectively. Both 14 and 15 could be also used for fluorescence imaging of Bacillus subtilis.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Li-Sheng Zhou, Ke-Wu Yang, Lei Feng, Jian-Min Xiao, Cheng-Cheng Liu, Yi-Lin Zhang, Michael W. Crowder,