| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372985 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
The structure–activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described. The optimization of the initial lead compound 6 based on in vitro and in vivo activity led to the discovery of key compounds 10j and 17h.
Graphical abstractThe structure–activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described. The optimization of the initial lead compound 6 based on in vitro and in vivo activity led to the discovery of key compounds 10j and 17h.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Organic Chemistry
Authors
Pauline C. Ting, Joe F. Lee, Nicolas Zorn, Hyunjin M. Kim, Robert G. Aslanian, Mingxiang Lin, Michelle Smith, Scott S. Walker, John Cook, Margaret Van Heek, Jean Lachowicz,