| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372987 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Structure–activity relationship (SAR) of a novel, potent and metabolically stable series of benzo [3.2.1] bicyclic sulfonamide-pyrazoles as γ-secretase inhibitors are described. Compounds that are efficacious in reducing the cortical Aβx-40 levels in FVB mice via oral dose, as well as those with high selectivity over Notch, are highlighted.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors](/preview/png/1372987.png "First Page Preview: Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors")
Authors
Xiaocong M. Ye, Andrei W. Konradi, Minghua Sun, Shendong Yuan, Danielle L. Aubele, Michael Dappen, Darren Dressen, Albert W. Garofalo, Jacek J. Jagodzinski, Lee Latimer, Gary D. Probst, Hing L. Sham, David Wone, Ying-zi Xu, Daniel Ness,