| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1372999 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Optimization of the ADME properties of a series of 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase resulted in the identification of highly selective compounds with properties suitable for use as in vitro and in vivo tools to probe the effects of Sky inhibition.
Graphical abstractOptimization of the ADME properties of a series of 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase resulted in the identification of highly selective compounds with properties suitable for use as in vitro and in vivo tools to probe the effects of Sky inhibitionFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Noel A. Powell, Jennifer K. Hoffman, Fred L. Ciske, Jeffrey T. Kohrt, Sangita M. Baxi, Yun-Wen Peng, Min Zhong, Cornel Catana, Jeff Ohren, Lisa A. Perrin, Jeremy J. Edmunds,