Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373010 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
Substituted 1,4-dihydropyridines were discovered as a novel and potent series of phosphodiesterase 4 (PDE4) inhibitors. Structure–activity relationships within this series have been carried out and studies revealed that the dihydropyridine core, with indole moiety and 3,4-dimethoxybenzyl group, is a potent analogue for PDE4 inhibition. These novel series of compounds were prepared via a 3-component reaction in a single pot. In vitro biological activity, modeling studies and crystallography data are also reported.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rajamohan R. Poondra, Ratnam V. Nallamelli, Chandana Lakshmi Teja Meda, B.N.V. Srinivas, Anushka Grover, Jyotsna Muttabathula, Sreedhara R. Voleti, Balasubramanian Sridhar, Manojit Pal, Kishore V.L. Parsa,