| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373015 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Due to the emergence of drug-resistant strains and the cumulative toxicities associated with current therapies, demand remains for new inhibitors of HIV-1 replication. The HIV-1 matrix (MA) protein is an essential viral component with established roles in the assembly of the virus. Using virtual and surface plasmon resonance (SPR)-based screening, we describe the identification of the first small molecule to bind to the HIV-1 MA protein and to possess broad range anti-HIV properties.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Isaac Zentner, Luz-Jeannette Sierra, Lina Maciunas, Andrei Vinnik, Peter Fedichev, Marie K. Mankowski, Roger G. Ptak, Julio Martín-García, Simon Cocklin,