| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373026 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
This communication reports a new synthetic route of pyridopyrimidines to facilitate their structural optimization in a library fashion and describes the development of pyridopyrimidines that have excellent enzymatic and cell potency against Akt1 and Akt2. This series also shows a high level of selectivity over other closely related kinases and significantly improved caspase-3 activity with the more optimized compounds.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhicai Wu, John C. Hartnett, Lou Anne Neilson, Ronald G. Robinson, Sheng Fu, Stanley F. Barnett, Deborah Defeo-Jones, Raymond E. Jones, Astrid M. Kral, Hans E. Huber, George D. Hartman, Mark T. Bilodeau,