| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373027 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
The design and profile of a series of adamantyl-containing long acting β2-adrenoreceptor agonists are described. An optimal pharmacokinetic profile of low oral bioavailability was combined with a strong pharmacology profile when assessed using a guinea pig trachea tissue model. A focus was then placed on developing a robust synthetic route to ensure rapid delivery of material for clinical trials.
Graphical abstractThe design and profile of a series of adamantyl-containing long acting β2-adrenoreceptor agonists are described. An optimal pharmacokinetic profile of low oral bioavailability was combined with a strong pharmacology profile when assessed using a guinea pig trachea tissue model. A focus was then placed on developing a robust synthetic route to ensure rapid delivery of material for clinical trials.Figure optionsDownload full-size imageDownload as PowerPoint slide
