| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373031 | Bioorganic & Medicinal Chemistry Letters | 2008 | 7 Pages |
Abstract
A series of substituted 3,6-diphenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines were prepared and analyzed as inhibitors of phosphodiesterase 4 (PDE4). Synthesis, structure–activity relationships, and the selectivity of a highly potent analogue against related phosphodiesterase isoforms are presented.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Amanda P. Skoumbourdis, Ruili Huang, Noel Southall, William Leister, Vicky Guo, Ming-Hsuang Cho, James Inglese, Marshall Nirenberg, Christopher P. Austin, Menghang Xia, Craig J. Thomas,