| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373033 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chunhui Zhou, Jaeki Min, Zhigang Liu, Anne Young, Heather Deshazer, Tian Gao, Young-Tae Chang, Neville R. Kallenbach,