| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373040 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Derivatives of milnacipran were synthesized and studied as monoamine transporter inhibitors. Potent analogs were discovered at NET (9k) and at both NET and SERT (9s and 9u). A pharmacophore model was established based on the conformational analysis of milnacipran in aqueous solution using NMR techniques and was consistent with the SAR results.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chen Chen, Brian Dyck, Beth A. Fleck, Alan C. Foster, Jonathan Grey, Florence Jovic, Michael Mesleh, Kasey Phan, Junko Tamiya, Troy Vickers, Mingzhu Zhang,