| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373042 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
A new sub-family of pyrrolotriazine analogs was identified as the potent VEGFR-2 kinase inhibitors. Antitumor efficacy was observed with compound 37 against L2987 human lung carcinoma xenografts in athymic mice.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis, SAR, and Evaluation of 4-[2,4-Difluoro-5-(cyclopropylcarbamoyl)phenylamino]pyrrolo[2,1-f][1,2,4]triazine-based VEGFR-2 kinase inhibitors](/preview/png/1373042.png "First Page Preview: Synthesis, SAR, and Evaluation of 4-[2,4-Difluoro-5-(cyclopropylcarbamoyl)phenylamino]pyrrolo[2,1-f][1,2,4]triazine-based VEGFR-2 kinase inhibitors")
Authors
Zhen-wei Cai, Donna Wei, Robert M. Borzilleri, Ligang Qian, Amrita Kamath, Steven Mortillo, Barri Wautlet, Benjamin J. Henley, Robert Sr., John Tokarski, John T. Hunt, Rajeev S. Bhide, Joseph Fargnoli, Louis J. Lombardo,