| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373043 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
A diversity-oriented synthesis has been developed for facile construction of a library of carbohydrate–cyclopamine conjugates. The synthetic protocol is suitable for generating cyclopamine derivatives with various structural motifs for exploring the desired activity. From this initial library, we have observed one derivative that exhibits improved activity against lung cancer cell as compared to cyclopamine.
Graphical abstractA diversity-oriented synthesis has been developed for facile construction of a library of carbohydrate–cyclopamine conjugates. The synthetic protocol is suitable for generating cyclopamine derivatives with various structural motifs for exploring the desired activity. From this initial library, we have observed one derivative that exhibits improved activity against lung cancer cell as compared to cyclopamine.Figure optionsDownload full-size imageDownload as PowerPoint slide
