| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373049 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A series of C5-aza tricyclic HIV integrase inhibitors was prepared. A highly potent and orally bioavailable compound (compound 9) was identified and selected for development.
Graphical abstractThe design and preparation of highly potent tricyclic HIV integrase inhibitors are reported. The lead compound has shown good oral bioavailability in both rat and dog.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Haolun Jin, Matthew Wright, Richard Pastor, Michael Mish, Sammy Metobo, Salman Jabri, Rachael Lansdown, Ruby Cai, Peter Pyun, Manuel Tsiang, Xiaowu Chen, Choung U. Kim,