| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373050 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Diversely substituted 2-pyrrolines have been prepared by a novel multicomponent process involving a reaction of various N-(aryl- and alkylsulfonamido)-acetophenones with aldehydes and malononitrile. While the reaction is highly regioselective, it is not stereoselective, generating a mixture of cis and trans 2-pyrrolines. A number of analogs from both cis and trans 2-pyrroline libraries were found to have antiproliferative activity in human cancer cell lines.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Igor V. Magedov, Giovanni Luchetti, Nikolai M. Evdokimov, Madhuri Manpadi, Wim F.A. Steelant, Severine Van slambrouck, Paul Tongwa, Mikhail Yu. Antipin, Alexander Kornienko,