| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373052 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
This paper describes the lead optimization of a new series of potent, selective, orally bioavailable, brain-penetrant MCH-1 receptor antagonists. A major focus of the work was to achieve a selectivity profile appropriate for in vivo efficacy studies and safety.
Graphical abstractThe design and synthesis of potent and selective indanylmethylpiperidine-based MCHR1 antagonists is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shawn D. Erickson, Bruce Banner, Steven Berthel, Karin Conde-Knape, Fiorenza Falcioni, Irina Hakimi, Bernard Hennessy, Robert F. Kester, Kyungjin Kim, Chun Ma, Warren McComas, Francis Mennona, Steven Mischke, Lucy Orzechowski, Yimin Qian, Hamid Salari,