Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373054 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. The synthesis, structure–activity relationships (SAR), metabolic stability, and structure-based design approach for this new class of compounds are discussed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yuefen Zhou, Stephen E. Webber, Douglas E. Murphy, Lian-Sheng Li, Peter S. Dragovich, Chinh V. Tran, Zhongxiang Sun, Frank Ruebsam, Amit M. Shah, Mei Tsan, Richard E. Showalter, Rupal Patel, Bin Li, Qiang Zhao, Qing Han, Thomas Hermann,