Article ID Journal Published Year Pages File Type
1373054 Bioorganic & Medicinal Chemistry Letters 2008 6 Pages PDF
Abstract

5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. The synthesis, structure–activity relationships (SAR), metabolic stability, and structure-based design approach for this new class of compounds are discussed.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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