Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373055 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. The structure–activity relationship (SAR) associated with variation of the pyridazinone 2- and 6-substituents is discussed. The synthesis and metabolic stability of this new class of compounds are also described.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yuefen Zhou, Lian-Sheng Li, Peter S. Dragovich, Douglas E. Murphy, Chinh V. Tran, Frank Ruebsam, Stephen E. Webber, Amit M. Shah, Mei Tsan, April Averill, Richard E. Showalter, Rupal Patel, Qing Han, Qiang Zhao, Thomas Hermann, Charles R. Kissinger,