Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373072 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Three sets of novel 4-deoxy-l-arabinose analogs were synthesized and evaluated as potential inhibitors of the bacterial resistance mechanism in which lipid A, on the outer membrane, is modified with 4-amino-4-deoxy-l-arabinose (l-Ara4N). One compound diminished the transfer of l-Ara4N onto lipid A. These results suggest that small molecules might be designed that would effect the same reversal of bacterial resistance observed in genetic knockouts.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
T. Kline, M.S. Trent, C.M. Stead, M.S. Lee, M.C. Sousa, H.B. Felise, H.V. Nguyen, S.I. Miller,