| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373073 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Four flavones, 3,4′-O-dimethylquercetin (1), 3,7-O-dimethylquercetin (2), 3-O-methylquercetin (3) and 3,7,4′-O-trimethylquercetin (4) were isolated as the inhibitors of nitric oxide production in activated microglia (IC50 values: 11.1, 4.2, 3.8, and 25.1 μM, respectively). They suppressed the expression of protein and mRNA of inducible nitric oxide synthase. Furthermore, compounds 2 and 3 showed scavenging activity of peroxynitrite with SC50 values of 1.75 and 0.77 μM, respectively.
Graphical abstractFour quercetin derivatives from Siegesbeckia glabrescens inhibited the production of nitric oxide and the expression of iNOS in LPS-activated microglia.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jae Yeon Kim, Hyo Jin Lim, Jae-Ha Ryu,