| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373076 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Curcumin has been extensively studied for its anti-inflammatory activities. However, its potential beneficial effects on various disease preventions and treatments are limited by its unstable structure. The β-diketone moiety renders curcumin to be rapidly metabolized by aldo–keto reductase in liver. In the present study, a series of curcumin analogues with more stable chemical structures were synthesized and several compounds showed an enhanced ability to inhibit lipopolysaccharide (LPS)-induced TNF-α and IL-6 synthesis in macrophages.
Graphical abstractA series of mono-carbonyl curcumin analogues with more stable chemical structures were synthesized and several compounds showed an enhanced ability to inhibit lipopolysaccharide (LPS)-induced TNF-α and IL-6 synthesis in macrophages.Figure optionsDownload full-size imageDownload as PowerPoint slide
