Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: Part 2

A second wave of potential SSRIs with high ease of synthetic accessibility were designed based on the reported selective serotonin re-uptake inhibitor litoxetine and our own previous work in this area. Preparation and subsequent optimisation yielded a range of potent and highly selective SSRIs.

Graphical abstractThe reported selective serotonin re-uptake inhibitor (SSRI) litoxetine was used as the starting point in the design of a second wave of potent, selective SSRIs with high ease of synthetic accessibility.Figure optionsDownload full-size imageDownload as PowerPoint slide