Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373140 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
We sought to design dual pharmacology bronchodilators targeting both the M3 muscarinic acetylcholine and beta-2 adrenergic (β2) receptors by applying our multivalent approach to drug discovery. Herein, we describe our initial discovery and the SAR of the first such compounds with matched potencies at both receptors.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Adam D. Hughes, Kay H. Chin, Sarah L. Dunham, Jeffrey R. Jasper, Kristin E. King, Tae Weon Lee, Mathai Mammen, Jerri Martin, Tod Steinfeld,