| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373148 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Structure–activity relationship of sphingosine-1-phosphate receptor agonist was examined. In terms of reducing the flexibility of molecule, hit compound 1 was modified to improve S1P1 agonistic activity as well as selectivity over S1P3 agonistic activity. Novel S1P agonists with cinnamyl scaffold or 1,2,5,6-tetrahydropyridine scaffold were identified.
Graphical abstractStructure–activity relationship of sphingosine-1-phosphate receptor agonist was examined. Novel S1P agonists with cinnamyl scaffold or 1,2,5,6-tetrahydropyridine scaffold were identified.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Haruto Kurata, Kazuhiro Otsuki, Kensuke Kusumi, Masakuni Kurono, Masahiko Terakado, Takuya Seko, Hirotaka Mizuno, Takeji Ono, Hiroshi Hagiya, Masashi Minami, Shinji Nakade, Hiromu Habashita,