| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373149 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
We describe the synthesis and potency of a novel series of N-substituted 2-phenyl- and 2-methyl-2-phenyl-1,4-diaminobutane- based CCR5 antagonists. Compounds 7a and 12f were found to be potent in anti-HIV assays and bioavailable in the low-dose rat PK model.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Matthew D. Tallant, Maosheng Duan, George A. Freeman, Robert G. Ferris, Mark P. Edelstein, Wieslaw M. Kazmierski, Pat J. Wheelan,