| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373154 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
A novel series of CXCR4 antagonists were identified based on the substantial redesign of AMD070. These compounds possessed potent anti-HIV-1 activity and showed excellent pharmacokinetics in rat and dog.
Graphical abstractA novel series of CXCR4 antagonists were identified based on the substantial redesign of AMD070. These compounds possessed potent anti-HIV-1 activity and showed excellent pharmacokinetics in rat and dog.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Renato Skerlj, Gary Bridger, Ernest McEachern, Curtis Harwig, Chris Smith, Alan Kaller, Duane Veale, Helen Yee, Krystyna Skupinska, Rossana Wauthy, Letian Wang, Ian Baird, Yongbao Zhu, Kate Burrage, Wen Yang, Michael Sartori, Dana Huskens,