| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373158 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
The synthesis and structure–activity relationships for a novel series of 6-amino-4-(pyrimidin-4-yl)pyridones derived from a high throughput screening hit are discussed. Optimization of lead matter afforded compounds with good potency, selectivity and central nervous system (CNS) exposure.
Graphical abstractThe synthesis and structure–activity relationships for a novel series of 6-amino-4-(pyrimidin-4-yl)pyridones derived from a high throughput screening hit are discussed. Optimization of lead matter afforded compounds with good potency, selectivity and central nervous system (CNS) exposure.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Karen Coffman, Michael Brodney, James Cook, Lorraine Lanyon, Jayvardhan Pandit, Subas Sakya, Joel Schachter, Elaine Tseng-Lovering, Matthew Wessel,