Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373171 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
2′,3′-Bis-O-tert-butyldimethylsilyl-5′-deoxy-5′-[N-(methylcarbamoyl)amino]-N6-(N-phenylcarbamoyl)adenosine, a new member of the N6,5′-bis-ureidoadenosine class of anticancer nucleosides, is found to exhibit broad spectrum antiproliferative activity. A majority of the cell lines in the NCI-60 are inhibited with an average GI50 = 3.13 μM. Selective toxicity against human colon cancer cell lines (COLO 205, HCC-2998, HCT-116, HT29, KM12) was also exhibited (LC50’s = 6–10 μM).
Graphical abstractA majority of cell lines in the NCI-60 are inhibited with an average GI50 = 3.13 μM. Selective toxicity against human colon cancer cell lines (COLO 205, HCC-2998, HCT-116, HT29, KM12) was also exhibited (LC50’s = 6–10 μM).Figure optionsDownload full-size imageDownload as PowerPoint slide