| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373185 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
The synthesis of diverse functionalized ureas in a semi-parallel fashion is described, as well as their β1/β2-adrenergic activities and the corresponding structure-activity relationship (SAR). We have focused on lipophilicity and duration of action, and we have discovered a strong correlation in this series of molecules. A quantitative structure-activity relationship (QSAR) analysis will be presented that quantifies this relationship.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Daniel Pérez, Maribel Crespo, Laia Solé, Maria Prat, Carla Carcasona, Elena Calama, Raquel Otal, Amadeu Gavaldá, Mireia Gómez-Angelats, Montserrat Miralpeix, Carles Puig,