Article ID Journal Published Year Pages File Type
1373197 Bioorganic & Medicinal Chemistry Letters 2007 4 Pages PDF
Abstract

In the course of our research program to develop novel muscarinic receptor antagonists for the treatment of COPD, new tropane carbamate derivatives were identified as potent anti-muscarinic agents. The synthesis, structure–activity relationships and pharmacological evaluation that led to the identification of compound 5o, are described.

Graphical abstractIn the course of our research program to develop novel muscarinic receptor antagonists for the treatment of COPD, new tropane carbamate derivatives were identified as potent anti-muscarinic agents. The synthesis, structure–activity relationships, and pharmacological evaluation that led to the identification of compound 5o are described.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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