Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373203 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Pyrrolopyrimidine, a novel scaffold, allows to adjust interactions within the S3 subsite of cathepsin K. The core intermediate 10 facilitated the P3 optimization and identified highly potent and selective cathepsin K inhibitors 11–20.
Graphical abstractPyrrolopyrimidine, a novel scaffold, allows to adjust interactions within the S3 subsite of cathepsin K. The core intermediate 10 facilitated the P3 optimization and identified highly potent and selective cathepsin K inhibitors.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Naoki Teno, Takahiro Miyake, Takeru Ehara, Osamu Irie, Junichi Sakaki, Osamu Ohmori, Hiroki Gunji, Naoko Matsuura, Keiichi Masuya, Yuko Hitomi, Kazuhiko Nonomura, Miyuki Horiuchi, Keigo Gohda, Atsuko Iwasaki, Ichiro Umemura, Sachiyo Tada,