Article ID Journal Published Year Pages File Type
1373212 Bioorganic & Medicinal Chemistry Letters 2007 4 Pages PDF
Abstract

The structure–activity relationships of new quinoline based compounds were investigated. Quinoline-5,8-dione and styrylquinoline scaffolds were used for the design of potentially active compounds. The novel analogues had comparable antiproliferative activity to cisplatin when evaluated in a bioassay against the P388 leukemia cell line. However, these compounds appeared far less efficient against SK-N-MC neuroepithelioma cells. Analogues without the 5,8-dione structure but containing the 8-carboxylic acid group were also found to induce antiproliferative activity. Hydrophobicity as measured by HPLC did not correlate with antiproliferative activity.

Graphical abstractThe structure–activity relationships of new quinoline-5,8-diones and quinolinecarboxylic acids exhibiting antiproliferative activity were investigated.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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