Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373212 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
The structure–activity relationships of new quinoline based compounds were investigated. Quinoline-5,8-dione and styrylquinoline scaffolds were used for the design of potentially active compounds. The novel analogues had comparable antiproliferative activity to cisplatin when evaluated in a bioassay against the P388 leukemia cell line. However, these compounds appeared far less efficient against SK-N-MC neuroepithelioma cells. Analogues without the 5,8-dione structure but containing the 8-carboxylic acid group were also found to induce antiproliferative activity. Hydrophobicity as measured by HPLC did not correlate with antiproliferative activity.
Graphical abstractThe structure–activity relationships of new quinoline-5,8-diones and quinolinecarboxylic acids exhibiting antiproliferative activity were investigated.Figure optionsDownload full-size imageDownload as PowerPoint slide